Krt14^tm1Efu
Targeted Allele Detail

Summary

• Symbol: Krt14^tm1Efu
• Name: keratin 14; targeted mutation 1, Elaine Fuchs
• MGI ID: MGI:2429386
• Synonyms: K14 -
• Gene: Krt14 Location: Chr11:100093988-100098336 bp, - strand Genetic Position: Chr11, 63.43 cM, cytoband D
• Alliance: Krt14^tm1Efu page

Krt14^tm1Efu/Krt14^tm1Efu mice exhibit gross blistering over body surface

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25763
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The endogenous gene was disrupted by the insertion of a cassette containing human vimetin (VIM) sequence followed by growth hormone sequence and PGK-neo. Though the VIM sequence was inserted at the endogenous start codon, the transgene was not expressed. Northern and Western blot analyses indicated an absence of both endogenous transcript and protein in homozygous mutant mice. (J:25763)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krt14 Mutation: 36 strains or lines available

References

• Original: J:25763 Lloyd C, et al., The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14. J Cell Biol. 1995 Jun;129(5):1329-44
• All: 5 reference(s)