About   Help   FAQ
Targeted Allele Detail
Symbol: Krt14tm1Efu
Name: keratin 14; targeted mutation 1, Elaine Fuchs
MGI ID: MGI:2429386
Synonyms: K14 -
Gene: Krt14  Location: Chr11:100093988-100098336 bp, - strand  Genetic Position: Chr11, 63.43 cM, cytoband D
Krt14tm1Efu/Krt14tm1Efu mice exhibit gross blistering over body surface

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:25763
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe endogenous gene was disrupted by the insertion of a cassette containing human vimetin (VIM) sequence followed by growth hormone sequence and PGK-neo. Though the VIM sequence was inserted at the endogenous start codon, the transgene was not expressed. Northern and Western blot analyses indicated an absence of both endogenous transcript and protein in homozygous mutant mice. (J:25763)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Krt14 Mutation:  6 strains or lines available
Original:  J:25763 Lloyd C, et al., The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14. J Cell Biol. 1995 Jun;129(5):1329-44
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.17
The Jackson Laboratory