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Cyp19a1tm1Sih
Targeted Allele Detail
Summary
Symbol: Cyp19a1tm1Sih
Name: cytochrome P450, family 19, subfamily a, polypeptide 1; targeted mutation 1, Shin-ichiro Honda
MGI ID: MGI:2389548
Synonyms: ArKO
Gene: Cyp19a1  Location: Chr9:54073221-54175394 bp, - strand  Genetic Position: Chr9, 29.49 cM
Alliance: Cyp19a1tm1Sih page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51076
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encompassing the proximal promoter and exons 1 and 2 was replaced by a neomycin selection inserted by homologous recombination. The deleted region included transcriptional and translational start sites and encoded amino acids essential for transmembrane topology. RT-PCR analysis of ovary and brain tissue indicated an absence of transcript in homozygous mutant mice. (J:51076)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp19a1 Mutation:  34 strains or lines available
References
Original:  J:51076 Honda S, et al., Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene. Biochem Biophys Res Commun. 1998 Nov 18;252(2):445-9
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory