Cyp19a1tm1Sih
Targeted Allele Detail
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Symbol: |
Cyp19a1tm1Sih |
Name: |
cytochrome P450, family 19, subfamily a, polypeptide 1; targeted mutation 1, Shin-ichiro Honda |
MGI ID: |
MGI:2389548 |
Synonyms: |
ArKO |
Gene: |
Cyp19a1 Location: Chr9:54073221-54175394 bp, - strand Genetic Position: Chr9, 29.49 cM
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Alliance: |
Cyp19a1tm1Sih page
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Germline Transmission: |
Earliest citation of germline transmission:
J:51076
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Parent Cell Line: |
CCE/EK.CCE (ES Cell)
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Strain of Origin: |
129S/SvEv-Gpi1c
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Sequence encompassing the proximal promoter and exons 1 and 2 was replaced by a neomycin selection inserted by homologous recombination. The deleted region included transcriptional and translational start sites and encoded amino acids essential for transmembrane topology. RT-PCR analysis of ovary and brain tissue indicated an absence of transcript in homozygous mutant mice.
(J:51076)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cyp19a1 Mutation: |
34 strains or lines available
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Original: |
J:51076 Honda S, et al., Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene. Biochem Biophys Res Commun. 1998 Nov 18;252(2):445-9 |
All: |
28 reference(s) |
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