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Mt3tm1Rpa
Targeted Allele Detail
Nomenclature
Symbol: Mt3tm1Rpa
Name: metallothionein 3; targeted mutation 1, Richard D Palmiter
MGI ID: MGI:2389488
Synonyms: Mt3-
Gene: Mt3  Location: Chr8:94152607-94154148 bp, + strand  Genetic Position: Chr8, 46.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38222
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details2.2 kb of sequence, encompassing the promoter and exons 1 and 2, was replaced by a neomycin selection cassette. Quantitative solution hybridization showed an absence of transcript in samples derived from homozygous mutant mice. (J:38222)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mt3 Mutation:  3 strains or lines available
References
Original:  J:38222 Erickson JC, et al., Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures. J Neurosci. 1997 Feb 15;17(4):1271-81
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory