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Targeted Allele Detail
Symbol: Smad2tm2Kato
Name: SMAD family member 2; targeted mutation 2, Mitsuyasu Kato
MGI ID: MGI:2389479
Gene: Smad2  Location: Chr18:76241580-76310963 bp, + strand  Genetic Position: Chr18, 51.42 cM
Germline Transmission:  Earliest citation of germline transmission: J:79668
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3 and 4 were deleted by the homologous recombination of a construct containing lacZ preceded by a splice acceptor site, enhancer sequence, and nuclear localiztion signal and followed by a floxed neo gene. (J:79668)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad2 Mutation:  16 strains or lines available
Original:  J:79668 Hamamoto T, et al., Compound disruption of smad2 accelerates malignant progression of intestinal tumors in apc knockout mice. Cancer Res. 2002 Oct 15;62(20):5955-61
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory