About   Help   FAQ
Bcmd2A/WySnJ
QTL Variant Detail
Summary
QTL variant: Bcmd2A/WySnJ
Name: B cell maturation defect 2; A/WySnJ
MGI ID: MGI:2389405
QTL: Bcmd2  Location: Chr4:133154678-150789451 bp  Genetic Position: Chr4, Syntenic
Variant
origin
Strain of Specimen:  A/WySnJ
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:75340

A second locus affecting B-lymphocyte deficiency and mastocytosis, Bcmd2, was mapped to an interval on mouse Chromosome 4 between D4Mit204 and D4Mit190 using an (A/WySnJ x CAST/Ei)F2 cross and controlling for Bcmd1 on chromosome 15. Parental strain A/WySnJ exhbits defective B-cell and mast cell homeostasis whereas parental strain CAST/Ei does not. Bcmd2 reached an LRS significance level of >10.4 between D4Mit204 and D4Mit190. Bcmd2 is a minor modifying locus controlling approximately 15% of the phenotypic difference. The Bcmd1 locus was fine-mapped to a 1.8 cM interval between D15Mit259 and D15Mit118 using extreme progeny from the (A/WySnJ x CAST/Ei)F2 cross and 630 animals from an (A/WySnJ x CAST/Ei)F1 x A/WySnJ backcross. A potential candidate gene for Bcmd1 is Blk. Bcmd1 and Bcmd2 were further verified in congenic strains created by introgressing either the Bcmd1 or Bcmd2 locus from CAST/Ei donor DNA onto the genetic background of A/WySnJ. Interestingly, the AW.CAST-Bcmd2 congenic exhibits mastocytosis but not B-lymphocyte deficiency suggesting mastocytosis is controlled by a different gene or genes.

References
Original:  J:75340 Clise-Dwyer K, et al., Genetic studies of B-lymphocyte deficiency and mastocytosis in strain A/WySnJ mice. Immunogenetics. 2001 Dec;53(9):729-35
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory