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QTL Variant Detail
QTL variant: Bbaa14C3H/HeJ
Name: B.burgdorferi-associated arthritis 14; C3H/HeJ
MGI ID: MGI:2389400
QTL: Bbaa14  Location: Chr15:31927441-31927610 bp  Genetic Position: Chr15, Syntenic
Strain of Specimen:  C3H/HeJ
Allele Type:    QTL
Mutation:    Undefined
Mutation detailsThis allele confers susceptibility to B.burgdorferi-associated arthritis and increased arthritis severity compared to C57BL/6N. (J:73060)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures

Mapping and Phenotype information for this QTL, its variants and associated markers


Composite interval mapping (CIM) was used for localization of QTL involved in modulating response to infection with Borrelia burgdorferi. Parental strains C3H/HeN and C3H/HeJ are susceptible to B.burgdorferi-induced arthritis whereas parental strains C57BL/6N and BALB/cAnN are resistant. Four different backcrosses and the reanalysis of a previous intercross were performed.

In the (C3H/HeJ X BALB/cAnN)F1 X BALB/cAnN backcross a novel QTL, Bbaa14 linked to ankle swelling mapped to Chr 15 at 17.8 cm with marker D15Mit111, LRT=15.1 accounting for 11.9% of trait variance. [Table 2.]

In the (C57BL/6N X C3H/HeJ)F1 X C57BL/6J backcross another Chr 15 QTL, linked to specific IgG, was also identified as Bbaa14. Since the two mapping populations differ curators named this QTL Bbaa31. Bbaa31 mapped from 15.6-18.8 cM between markers D15Mit24 and D15Mit154, LRT=18.3 accounting for 12.3% of variance. [Table 2.]

In the reanalysis of the (C57BL/6N X C3H/HeN)F2 intercross a novel QTL, Bbaa22, linked to histopathology mapped to 46.9 cM with marker D15Mit24, LRT=19.8 accounting for 17.3% of variance. [Table 2.]

C3H/HeN-derived alleles are associated with increased arthritis susceptibility and severity at all QTL mapped in this experiment.

Original:  J:73060 Roper RJ, et al., Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun. 2001 Nov;2(7):388-97
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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