Bbaa21^C3H/HeN
QTL Variant Detail

Summary

• QTL variant: Bbaa21^C3H/HeN
• Name: B.burgdorferi-associated arthritis 21; C3H/HeN
• MGI ID: MGI:2389331
• QTL: Bbaa21 Location: Chr14:60065847-60066045 bp Genetic Position: Chr14, cM position of peak correlated region/allele: 31.52 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/HeN

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers susceptibility to B.burgdorferi-associated arthritis and increased arthritis severity compared to C57BL/6N. (J:73060)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:73060

Composite interval mapping (CIM) was used for localization of QTL involved in modulating response to infection with Borrelia burgdorferi. Parental strains C3H/HeN and C3H/HeJ are susceptible to B.burgdorferi-induced arthritis whereas parental strains C57BL/6N and BALB/cAnN are resistant. Four different backcrosses and the reanalysis of a previous intercross were performed.

A novel QTL, Bbaa21, was identified in the (C57BL/6N X C3H/HeN)F1 X C57BL/6N backcross on Chr 14. Bbaa21 was linked to the number of B.burgdorferi in heart tissue post-infection. It mapped to 25.0 cM with marker D14Mit155, LRT=13.2 accounting for 9.8% variance.

[Table 2.]

C3H/HeN-derived alleles are associated with increased arthritis susceptibility and severity at all QTL mapped in this experiment.

References

• Original: J:73060 Roper RJ, et al., Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun. 2001 Nov;2(7):388-97
• All: 1 reference(s)