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Camk2atm3Sva
Targeted Allele Detail
Nomenclature
Symbol: Camk2atm3Sva
Name: calcium/calmodulin-dependent protein kinase II alpha; targeted mutation 3, Alcino Silva
MGI ID: MGI:2389262
Synonyms: alphaCaMKIIdelta
Gene: Camk2a  Location: Chr18:60925618-60988152 bp, + strand  Genetic Position: Chr18, 34.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79714
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 2 was flanked by loxP sites and excised in vitro by the transient expression of cre recombinase. The deletion of exon 2 results in a frameshift mutation affecting sequence downstream of exon 1. An absence of normal protein in homozygous mutant mice was confirmed by Western blot analysis. (J:79714)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Camk2a Mutation:  80 strains or lines available
References
Original:  J:79714 Elgersma Y, et al., Inhibitory Autophosphorylation of CaMKII Controls PSD Association, Plasticity, and Learning. Neuron. 2002 Oct 24;36(3):493-505
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory