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QTL Variant Detail
QTL variant: Renf1C57BL/6J
Name: renal failure 1; C57BL/6J
MGI ID: MGI:2389225
QTL: Renf1  Location: Chr9:52123178-99910428 bp  Genetic Position: Chr9, Syntenic
Strain of Specimen:  C57BL/6J
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


The Col4a3tm1Jhm mutation (the mouse model of Alport syndrome) was crossed onto a 129X1/SvJ background and a C57BL/6J background for 6 and 7 generations, respectively. This resulted in mutant lines composed of >98% 129X1/SvJ and >99% C57BL/6J background genetic material. The rate of end-stage renal failure (ESRF) progressed much more quickly in mutant animals on a 129X1/SvJ background (2 months) compared to mutant animals on a C57BL/6J background (> 6 months). Loci responsible for this difference in renal failure progression were mapped in a F1 x C57BL/6J backcross using markers spaced approximately 20 cM apart. Renf1 mapped to mouse Chromosome 9 at approximately 43 cM with a LOD score of 3.26 between D9Mit4 and D9Mit12, and Renf2 mapped to mouse Chromosome 16 at approximately 57 cM with a LOD score of 3.1 at D16Mit153.

Original:  J:74499 Andrews KL, et al., Quantitative trait loci influence renal disease progression in a mouse model of Alport syndrome. Am J Pathol. 2002 Feb;160(2):721-30
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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