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QTL Variant Detail
QTL variant: Bmd16C3H/HeJ
Name: bone mineral density 16; C3H/HeJ
MGI ID: MGI:2389179
QTL: Bmd16  Location: Chr18:46534847-46534993 bp  Genetic Position: Chr18, cM position of peak correlated region/allele: 19.41 cM
QTL Note: genome coordinates based on the boundaries of the QTL region
Strain of Specimen:  C3H/HeJ
Allele Type:    QTL
Mutation:    Undefined
Mutation detailsThis allele confers increased femoral and vertebral BMD and increased body weight compared to C57BL/6J. (J:78754)
Inheritance:    Other (see notes)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Bmd16 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers


Linkage analysis was performed on 986 (C57BL/6J x C3H/HeJ)F2 female animals using 107 microsatellite markers to identify QTLs associated with bone mineral density (BMD). Parental strain C3H/HeJ exhibits higher bone mineral density values compared to C57BL/6J. Bmd16 mapped to 24 cM on mouse Chromosome 18 with a peak LOD=13.67 at D18Mit36 in linkage to femoral and vertebral BMD. C3H/HeJ-derived alleles confer an additively-inherited increase in femoral and vertebral BMD at Bmd16.

Original:  J:78754 Beamer WG, et al., Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice. J Bone Miner Res. 2001 Jul;16(7):1195-206
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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