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Bmd11C57BL/6J
QTL Variant Detail
Nomenclature
QTL variant: Bmd11C57BL/6J
Name: bone mineral density 11; C57BL/6J
MGI ID: MGI:2389165
QTL: Bmd11  Location: Chr11:63428581-63428696 bp  Genetic Position: Chr11, cM position of peak correlated region/allele: 39.47 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Notes
Bmd11 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:78754

Linkage analysis was performed on 986 (C57BL/6J x C3H/HeJ)F2 female animals using 107 microsatellite markers to identify QTLs associated with bone mineral density (BMD). Parental strain C3H/HeJ exhibits higher bone mineral density values compared to C57BL/6J. Bmd11 mapped to 31 cM on mouse Chromosome 11 with a peak LOD=6.76 at D11Mit242 in linkage to femoral BMD (and suggestive linkage to vertebral BMD.) C3H/HeJ-derived alleles confer an additively-inherited increase in femoral and vertebral BMD at Bmd11.

References
Original:  J:78754 Beamer WG, et al., Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice. J Bone Miner Res. 2001 Jul;16(7):1195-206
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory