About   Help   FAQ
Hsl1C3H/HeJ
QTL Variant Detail
Nomenclature
QTL variant: Hsl1C3H/HeJ
Name: hyperoxia susceptibility locus 1; C3H/HeJ
MGI ID: MGI:2389122
QTL: Hsl1  Location: Chr2:80739810-80739957 bp  Genetic Position: Chr2, cM position of peak correlated region/allele: 48.5 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C3H/HeJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers resistance to hyperoxia compared to C57BL/6J.
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:73581

Linkage analysis was performed on (C57BL/6J x C3H/HeJ)F2 intercross animals and BXH RI strains to identify QTLs associated with susceptibility to hyperoxia. Parental strain C57BL/6J is susceptible to hyperoxia whereas C3H/HeJ is resistant. A locus named Hsl1, hyperoxia susceptibility locus 1, mapped to 48 cM on mouse Chromosome 2 in linkage to polymorphonuclear leukocyte (PMN) infiltration with LRS=13.2 at D2Mit248. Hsl1 is also linked to hyperoxia-induced changes in endothelial cell and macrophage levels. The QTL range of Hsl1 spans 45 cM - 49.2 cM on chromosome 2. C57BL/6J-derived alleles confer susceptibility to hyperoxia at this locus. A strong candidate gene for Hsl1 is Nfe2l2. Basal mRNA level of Nfe2l2 is 1.8-fold higher in C3H/HeJ animals compared to C57BL/6J, and the difference increases following hyperoxic lung injury. Sequence analysis detected a T to C substitution in the Nfe2l2 promoter region (position -336) in C57BL/6J, and the polymorphism was shown to segregate with the phenotype. A suggestive QTL, Hsl2, mapped from 51.1 cM - 58.5 cM on mouse Chromosome 3.

References
Original:  J:73581 Cho HY, et al., Linkage Analysis of Susceptibility to Hyperoxia. Nrf2 is a candidate gene. Am J Respir Cell Mol Biol. 2002 Jan 1;26(1):42-51
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/11/2020
MGI 6.14
The Jackson Laboratory