About   Help   FAQ
Taglntm1(cre/ERT2)Feil
Targeted Allele Detail
Nomenclature
Symbol: Taglntm1(cre/ERT2)Feil
Name: transgelin; targeted mutation 1, Robert Feil
MGI ID: MGI:2389040
Synonyms: SM22alphaCew-ERT2, SM-Cre ERT2(ki), SM-CreERT2(ki), SM-CreERT2(ki), Taglntm1(cre/ESR1)Feil
Gene: Tagln  Location: Chr9:45929628-45936058 bp, - strand  Genetic Position: Chr9, 25.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69325
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsAn allele encoding a tissue specific and ligand dependent recombinase was generated by inserting cre recombinase/modified estrogen receptor (ESR1) fusion sequence into the endogenous allele. The ESR1 sequence contained engineered missense mutations at positions 400, 543, 540 which substituted the ability to bind the endogenous ligand with the ability to bind tamoxifen (J:79835). Histochemical analysis of mutant mice treated with tamoxifen showed expression of cre in smooth muscle tissue. (J:69325)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tagln     Summary of all recombinase alleles driven by Tagln. Comparative matrix view of recombinase activities
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tagln Mutation:  20 strains or lines available
References
Original:  J:69325 Kuhbandner S, et al., Temporally controlled somatic mutagenesis in smooth muscle. Genesis. 2000 Sep;28(1):15-22
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory