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Transgene Detail
Symbol: Tg(Myh6-ADRBK1)27Wjk
Name: transgene insertion 27, Walter Koch
MGI ID: MGI:2389030
Synonyms: BetaARKct, TG betaARKct, Tg(minBARKct)27Wjk, TGMini27
Transgene: Tg(Myh6-ADRBK1)27Wjk  Location: unknown  
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Myh6-ADRBK1)27Wjk expresses 1 gene
Mutation detailsSequence encoding the carboxyl terminus of the bovine adrenergic receptor kinase, beta 1 (ADRBK1) (residues 495 through 689) was ligated to a 5.5 kb fragment of the murine adult myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6) promoter. The resultant 194 residue carboxyl terminal peptide was detected by Western blot analysis and inhibits endogenous beta-adrenergic receptor kinase-1 by blocking beta-adrenergic receptor desensitization. The Myh6 promoter drives expression in myocardial tissue. (J:37034)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:37034 Koch WJ, et al., Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science. 1995 Jun 2;268(5215):1350-3
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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