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Cdh1tm2Kem
Targeted Allele Detail
Nomenclature
Symbol: Cdh1tm2Kem
Name: cadherin 1; targeted mutation 2, Rolf Kemler
MGI ID: MGI:2389020
Synonyms: Ecadfl, E-cadherinflox, E-cadherinfloxed, E-cadlox
Gene: Cdh1  Location: Chr8:106603351-106670246 bp, + strand  Genetic Position: Chr8, 53.18 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77170
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSingle loxP sites flanked a region encompassing exons 6 through 10 followed by a floxed selection cassette was excised via in vitro cre mediated recombination. (J:77170)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdh1 Mutation:  118 strains or lines available
References
Original:  J:77170 Boussadia O, et al., E-cadherin is a survival factor for the lactating mouse mammary gland. Mech Dev. 2002 Jul;115(1-2):53-62
All:  49 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory