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Tg(KRT14-CASP1)1Miz
Transgene Detail
Nomenclature
Symbol: Tg(KRT14-CASP1)1Miz
Name: transgene insertion 1, Hitoshi Mizutani
MGI ID: MGI:2388821
Synonyms: KCASP1Tg
Transgene: Tg(KRT14-CASP1)1Miz  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(KRT14-CASP1)1Miz expresses 1 gene
 
Mutation details1.4 kb CASP1 cDNA was adjoined to the human keratin 14 (KRT14) promoter and rabbit beta-globin intron. The human keratin 14 promoter drives expression in epidermal tissue. Expression analysis showed transgenic expression in the skin, but not in liver, kidney, colon, lung, brain, or spleen tissue. (J:79706)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:79706 Yamanaka K, et al., Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18. J Immunol. 2000 Jul 15;165(2):997-1003
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory