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Tnfsf4tm1Sug
Targeted Allele Detail
Nomenclature
Symbol: Tnfsf4tm1Sug
Name: tumor necrosis factor (ligand) superfamily, member 4; targeted mutation 1, Kazuo Sugamura
MGI ID: MGI:2388724
Synonyms: OX40-KO, OX40L-
Gene: Tnfsf4  Location: Chr1:161223009-161245777 bp, + strand  Genetic Position: Chr1, 69.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:59412
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by FACS analysis of activated B cells obtained from homozygous mutant mice. (J:59412)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfsf4 Mutation:  20 strains or lines available
References
Original:  J:59412 Murata K, et al., Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. J Exp Med. 2000 Jan 17;191(2):365-74
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory