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Map3k8tm1Pnt
Targeted Allele Detail
Nomenclature
Symbol: Map3k8tm1Pnt
Name: mitogen-activated protein kinase kinase kinase 8; targeted mutation 1, Phillip Tsichlis
MGI ID: MGI:2388714
Synonyms: Map3k8tm1Ceci, Tpl2 -
Gene: Map3k8  Location: Chr18:4331327-4353015 bp, - strand  Genetic Position: Chr18, 2.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66503
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence extending from within exon 3 to within exon 5 was replaced by a neomycin selection cassette. The deleted region encoded a portion of the catalytic domain including ATP binding site and the activation loop. Transcript was detected by Northern blot analysis of homozygous mutant splenocytes. (J:66503)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map3k8 Mutation:  24 strains or lines available
References
Original:  J:66503 Dumitru CD, et al., TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell. 2000 Dec 22;103(7):1071-83
All:  42 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory