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Targeted Allele Detail
Symbol: Startm1Klp
Name: steroidogenic acute regulatory protein; targeted mutation 1, Keith L Parker
MGI ID: MGI:2388706
Gene: Star  Location: Chr8:25808474-25814723 bp, + strand  Genetic Position: Chr8, 14.17 cM
Histology of the adrenal gland from wild type and Startm1Klp/Startm1Klp mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:43589
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA portion of exon 2 and all of exon 3 were replaced with a neomycin selection cassette. Normal protein was undetected by Western blot analysis of adrenal extracts from homozygous mutant mice. (J:43589)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Star Mutation:  1 strain or line available
Original:  J:43589 Caron KM, et al., Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11540-5
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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