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Targeted Allele Detail
Symbol: Pdx1tm1Macd
Name: pancreatic and duodenal homeobox 1; targeted mutation 1, Raymond J MacDonald
MGI ID: MGI:2388676
Synonyms: Pdx1tTA
Gene: Pdx1  Location: Chr5:147206907-147212658 bp, + strand  Genetic Position: Chr5, 86.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:79206
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Transactivator)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 and 2, which encompass the entire coding region, were replaced with a cassette containing a tetracycline transactivator (tTA) and a neo resistance gene. RT-PCR showed tTA expression in adult pancreas tissue but not in other visceral organs or salivary glands. (J:79206)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 9 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdx1 Mutation:  28 strains or lines available
Original:  J:79206 Holland AM, et al., Experimental control of pancreatic development and maintenance. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12236-41
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory