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Targeted Allele Detail
Symbol: Pdx1tm1Macd
Name: pancreatic and duodenal homeobox 1; targeted mutation 1, Raymond J MacDonald
MGI ID: MGI:2388676
Synonyms: Pdx1tTA
Gene: Pdx1  Location: Chr5:147206907-147212658 bp, + strand  Genetic Position: Chr5, 86.84 cM
Alliance: Pdx1tm1Macd page
Germline Transmission:  Earliest citation of germline transmission: J:79206
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Transactivator)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 and 2, which encompass the entire coding region, were replaced with a cassette containing a tetracycline transactivator (tTA) and a neo resistance gene. RT-PCR showed tTA expression in adult pancreas tissue but not in other visceral organs or salivary glands. (J:79206)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 9 assay results
Tumor Data
List all tumor models in MMHCdb carrying Pdx1tm1Macd
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdx1 Mutation:  28 strains or lines available
Original:  J:79206 Holland AM, et al., Experimental control of pancreatic development and maintenance. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12236-41
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory