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Targeted Allele Detail
Symbol: Syt1tm6Sud
Name: synaptotagmin I; targeted mutation 6, Thomas C Sudhof
MGI ID: MGI:2388630
Synonyms: D238N
Gene: Syt1  Location: Chr10:108333511-108846843 bp, - strand  Genetic Position: Chr10, 56.52 cM
Germline Transmission:  Earliest citation of germline transmission: J:79208
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Disruption caused by insertion of vector
Mutation detailsAn aspartate to asparagine missense mutation (D238N) was introduced into the C2A domain via homologous recombination. The mutation was made in the C2A domain. Western blot of brain homogenates from homozygous mutant animals verified the presence of protein expression. (J:79208)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Syt1 Mutation:  33 strains or lines available
Original:  J:79208 Fernandez-Chacon R, et al., Structure/function analysis of Ca2+ binding to the C2A domain of synaptotagmin 1. J Neurosci. 2002 Oct 1;22(19):8438-46
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory