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Transgene Detail
Symbol: Tg(MtTGFA)42Lmb
Name: transgene insertion 42, Glenn Merlino
MGI ID: MGI:2388567
Synonyms: line MT42, MT42, MT-TGF-alpha, MT/TGF-alpha line MT42, TGF-alpha, Tg(Mt1-TGFA)42Lmb
Transgene: Tg(MtTGFA)42Lmb  Location: unknown  
Strain of Origin:  CD-1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(MtTGFA)42Lmb expresses 1 gene
Mutation detailsThis transgene contains the inducible mouse Mt1 (metallothionein) promoter, cDNA of the wild-type allele of the human TGFA (transforming growth factor alpha) gene, and a human growth hormone polyadenylation signal. Line 100, carrying 10 copies of the transgene was also produced (see Phenotypes
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Original:  J:28452 Jhappan C, et al., TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell. 1990 Jun 15;61(6):1137-46
All:  38 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory