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Tg(Ins1-GAS)1Sbr
Transgene Detail
Nomenclature
Symbol: Tg(Ins1-GAS)1Sbr
Name: transgene insertion 1, Stephen J Brand
MGI ID: MGI:2388566
Synonyms: INSGAS, INS-GAS
Transgene: Tg(Ins1-GAS)1Sbr  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/NTac
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ins1-GAS)1Sbr expresses 1 gene
 
Mutation details1.5 kb of human GAS sequences encoding the preprogastrin peptide precursor (intron 1, exon 2, and exon 3) was used for the transgene. Nucleotides -370 to +38 of the rat insulin 1 gene (Ins1) drive transgene expression in beta islet cells. (J:78615)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:78615 Wang TC, et al., Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells. J Clin Invest. 1993 Sep;92(3):1349-56
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory