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Nqo1tm1Akj
Targeted Allele Detail
Nomenclature
Symbol: Nqo1tm1Akj
Name: NAD(P)H dehydrogenase, quinone 1; targeted mutation 1, Anil K Jaiswal
MGI ID: MGI:2388490
Synonyms: NQO1 -
Gene: Nqo1  Location: Chr8:107388225-107403206 bp, - strand  Genetic Position: Chr8, 54.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46669
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 6 and flanking non-coding sequences were replaced with a 2 kb neomycin resistance cassette via homologous recombination. The targeted mutation results in deletion of 101 C-terminal residues and disrupts enzyme function. Gene expression was absent in homozygous mutant animals in all tissues examined (lung, liver, kidney, colong, skeletal muscle) by Northern blot and Western blot. (J:46669)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nqo1 Mutation:  13 strains or lines available
References
Original:  J:46669 Radjendirane V, et al., Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity. J Biol Chem. 1998 Mar 27;273(13):7382-9
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory