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Il6sttm1Ern
Targeted Allele Detail
Nomenclature
Symbol: Il6sttm1Ern
Name: interleukin 6 signal transducer; targeted mutation 1, Matthias Ernst
MGI ID: MGI:2388478
Synonyms: gp130757F, gp130F, gp130Y757F, gp130Y757F
Gene: Il6st  Location: Chr13:112464070-112506860 bp, + strand  Genetic Position: Chr13, 63.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79073
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsThe Ptpn11 binding domain, encoded by sequence in exon 17, was disrupted by homologous recombination of a construct containing missense mutations at codons 757 (tyrosine to phenylalanine) and 760 (valine to alanine). Furthermore, an IRES-neo cassette was inserted into the 3' region of exon 17. A biochemical assay of liver tissue showed that the Il6st mediated signalling pathway was disrupted in mutant mice. (J:79073)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 12 strains available      Cell Lines: 0 lines available
Carrying any Il6st Mutation:  30 strains or lines available
References
Original:  J:79073 Tebbutt NC, et al., Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med. 2002 Oct;8(10):1089-97
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory