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Krt6a/Krt6btm1Der
Targeted Allele Detail
Nomenclature
Symbol: Krt6a/Krt6btm1Der
Name: keratin 6A; targeted mutation 1, Dennis R Roop
MGI ID: MGI:2388395
Synonyms: K6ab-null, MK6a/b-
Gene: Krt6a  Location: Chr15:101689932-101694307 bp, - strand  Genetic Position: Chr15, 56.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70812
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsAn 18 kb region containing the entire coding sequences of Krt2-6a and Krt-6b, and including 10.5 kb of intervening sequences, was deleted and replaced with an HPRT-neo minigene via homologous recombination. Absence of expression of both genes in homozygous mutant animals was confirmed by RNase protection assay of skin and hair follicles. (J:70812)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Krt6a Mutation:  13 strains or lines available
References
Original:  J:70812 Wojcik SM, et al., Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b. J Cell Biol. 2001 Aug 6;154(3):619-30
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory