About   Help   FAQ
Tnfsf10tm1Sdg
Targeted Allele Detail
Nomenclature
Symbol: Tnfsf10tm1Sdg
Name: tumor necrosis factor (ligand) superfamily, member 10; targeted mutation 1, Lisa M Sedger
MGI ID: MGI:2388390
Synonyms: TRAIL-, TRAIL-Apo2L-
Gene: Tnfsf10  Location: Chr3:27317028-27342427 bp, + strand  Genetic Position: Chr3, 10.82 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79085
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA portion of exon 2 and all of exon 3 were replaced by a neomycin selection cassette inserted by homologous recombination. Splicing of untargeted exons results in a frameshift mutation. Truncated transcript was detected by RT-PCR analysis of RNA obtained from homozygous mutant splenocytes. A premature stop codon was identified by sequence analyis of this transcript. (J:79085)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfsf10 Mutation:  4 strains or lines available
References
Original:  J:79085 Sedger LM, et al., Characterization of the in vivo function of TNF-alpha-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice. Eur J Immunol. 2002 Aug;32(8):2246-54
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/10/2017
MGI 6.10
The Jackson Laboratory