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Targeted Allele Detail
Symbol: Tnfsf10tm1Sdg
Name: tumor necrosis factor (ligand) superfamily, member 10; targeted mutation 1, Lisa M Sedger
MGI ID: MGI:2388390
Synonyms: TRAIL-, TRAIL-Apo2L-
Gene: Tnfsf10  Location: Chr3:27317028-27342427 bp, + strand  Genetic Position: Chr3, 10.82 cM, cytoband A3
Germline Transmission:  Earliest citation of germline transmission: J:79085
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA portion of exon 2 and all of exon 3 were replaced by a neomycin selection cassette inserted by homologous recombination. Splicing of untargeted exons results in a frameshift mutation. Truncated transcript was detected by RT-PCR analysis of RNA obtained from homozygous mutant splenocytes. A premature stop codon was identified by sequence analyis of this transcript. (J:79085)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfsf10 Mutation:  4 strains or lines available
Original:  J:79085 Sedger LM, et al., Characterization of the in vivo function of TNF-alpha-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice. Eur J Immunol. 2002 Aug;32(8):2246-54
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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