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Rdh5tm1Drie
Targeted Allele Detail
Nomenclature
Symbol: Rdh5tm1Drie
Name: retinol dehydrogenase 5; targeted mutation 1, Carola A G G Driessen
MGI ID: MGI:2388375
Synonyms: 11-cis-rdh-
Gene: Rdh5  Location: Chr10:128913593-128922888 bp, - strand  Genetic Position: Chr10, 77.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77619
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exons 1-3 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was verified by RT-PCR analysis of total RNA from eyes and kidneys, and by Western blot analysis of eye protein extracts. (J:77619)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rdh5 Mutation:  0 strains or lines available
References
Original:  J:77619 Driessen CA, et al., Disruption of the 11-cis-retinol dehydrogenase gene leads to accumulation of cis-retinols and cis-retinyl esters. Mol Cell Biol. 2000 Jun;20(12):4275-87
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/11/2017
MGI 6.08
The Jackson Laboratory