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Targeted Allele Detail
Symbol: Kcnj1tm1Ges
Name: potassium inwardly-rectifying channel, subfamily J, member 1; targeted mutation 1, Gary E Shull
MGI ID: MGI:2388372
Synonyms: Romk-, ROMK(-)
Gene: Kcnj1  Location: Chr9:32372493-32399197 bp, + strand  Genetic Position: Chr9, 17.69 cM
Kcnj1tm1Ges/Kcnj1tm1Ges mice exhibit hydronephrosis

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:79354
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe exon encoding the majority the 391 amino acid protein product was disrupted by the insertion of a neomycin selection cassette. While normal transcript was undetected by Northern blot analysis of homozygous mutant mice, trace levels of an elongated transcript were detected with a 3' probe. (J:79354)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnj1 Mutation:  19 strains or lines available
Original:  J:79354 Lorenz JN, et al., Impaired Renal NaCl Absorption in Mice Lacking the ROMK Potassium Channel, a Model for Type II Bartter's Syndrome. J Biol Chem. 2002 Oct 4;277(40):37871-80
All:  9 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
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