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Adora1tm1Jgsc
Targeted Allele Detail
Nomenclature
Symbol: Adora1tm1Jgsc
Name: adenosine A1 receptor; targeted mutation 1, Jurgen Schnermann
MGI ID: MGI:2388340
Synonyms: A1-, A1AR-, A1KO
Gene: Adora1  Location: Chr1:134199223-134235431 bp, - strand  Genetic Position: Chr1, 58.15 cM, cytoband E4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71091
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire coding sequence of the gene was deleted and replaced with a lacZ-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of kidney mRNA. (J:71091)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adora1 Mutation:  1 strain or line available
References
Original:  J:71091 Sun D, et al., Mediation of tubuloglomerular feedback by adenosine: evidence from mice lacking adenosine 1 receptors. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9983-8
All:  57 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/07/2020
MGI 6.15
The Jackson Laboratory