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Targeted Allele Detail
Symbol: Hmox1tm1Poss
Name: heme oxygenase 1; targeted mutation 1, Kenneth D Poss
MGI ID: MGI:2388322
Synonyms: Hmox1-, HO-1-, HO1-
Gene: Hmox1  Location: Chr8:75093591-75100596 bp, + strand  Genetic Position: Chr8, 35.59 cM, cytoband C1
Iron-loading of Hmox1tm1Poss/Hmox1tm1Poss tissues.

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:79254
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 3.7 kb fragment encompassing exons 3, 4, and a portion of 5 was replaced with a neomycin selection cassette. The deleted region consisted of approximately 85% of the coding region (226 residues). A low level of aberrantly spliced transcript was identified in homozygous mutant mice by Northern blot analysis of total splenic RNA. (J:79254)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hmox1 Mutation:  19 strains or lines available
Phenotypic Similarity to Human Syndrome: Iron overload disorders including Hemochromatosis and Anemia of chronic inflammation in homozygous mice (J:79254)
Original:  J:79254 Poss KD, et al., Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10919-24
All:  39 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.04
The Jackson Laboratory