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Targeted Allele Detail
Symbol: Eif2s1tm1Rjk
Name: eukaryotic translation initiation factor 2, subunit 1 alpha; targeted mutation 1, Randal J Kaufman
MGI ID: MGI:2388264
Synonyms: eIF2alphaS51A, eIF2alphaS/A
Gene: Eif2s1  Location: Chr12:78908846-78933784 bp, + strand  Genetic Position: Chr12, 35.51 cM, cytoband D1
Germline Transmission:  Earliest citation of germline transmission: J:70004
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Not Specified)
Mutation:    Nucleotide substitutions
Mutation detailsA serine to alanine substitution at a phosphorylation site at position 51 (S51A) of exon 2 was introduced, and a floxed neomycin resistance cassette was inserted into the upstream intron for positive selection. The floxed neo cassette was removed by cre-mediated recombination leaving behind a single loxP site and the S51A mutation. Western blot analysis of mouse embryonic fibroblasts derived from homozygous mutant animals confirmed expression of the mutant allele. (J:70004)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Eif2s1 Mutation:  53 strains or lines available
Original:  J:70004 Scheuner D, et al., Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell. 2001 Jun;7(6):1165-76
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory