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Targeted Allele Detail
Symbol: Adamts2tm1Prc
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2; targeted mutation 1, Darwin J Prockop
MGI ID: MGI:2388161
Gene: Adamts2  Location: Chr11:50602085-50807573 bp, + strand  Genetic Position: Chr11, 30.78 cM
Germline Transmission:  Earliest citation of germline transmission: J:69141
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exon 14 and flanking intronic sequences with a neomycin resistance cassette. Northern blot analysis of fibroblasts from homozygous mutant animals did not detect RNA transcripts of any size. (J:69141)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adamts2 Mutation:  33 strains or lines available
Original:  J:69141 Li SW, et al., Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility. Biochem J. 2001 Apr 15;355(Pt 2):271-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory