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Vax2tm1Grl
Targeted Allele Detail
Nomenclature
Symbol: Vax2tm1Grl
Name: ventral anterior homeobox 2; targeted mutation 1, Greg Lemke
MGI ID: MGI:2388160
Synonyms: Vax2-
Gene: Vax2  Location: Chr6:83711264-83738313 bp, + strand  Genetic Position: Chr6, 35.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74240
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced by a neo cassette inserted by homologous recombination. RT-PCR analysis identified shortened transcript in homozygous mutant mice, lacking the targeted region, which encoded the first two alpha helices (residues 83 through 145) of the homeodomain. A loss of immunoreactivity was observed in the homozygous mutant retina. (J:74240)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 29 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vax2 Mutation:  9 strains or lines available
References
Original:  J:74240 Mui SH, et al., The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye. Development. 2002 Feb;129(3):797-804
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory