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Top3btm1Jcw
Targeted Allele Detail
Nomenclature
Symbol: Top3btm1Jcw
Name: topoisomerase (DNA) III beta; targeted mutation 1, James C Wang
MGI ID: MGI:2388157
Synonyms: top3beta-/-
Gene: Top3b  Location: Chr16:16870736-16892990 bp, + strand  Genetic Position: Chr16, 10.46 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69405
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA region of the gene spanning nucleotides 777 to 1490 of the coding sequence was replaced with a PGK-neo cassette. This region includes the active site tyrosine 336. Gene expression was undetectable by RT-PCR analysis of liver mRNA from homozygous mutant animals. (J:69405)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Top3b Mutation:  42 strains or lines available
References
Original:  J:69405 Kwan KY, et al., Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5717-21
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory