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Spontaneous Allele Detail
Symbol: Dstncorn1-2J
Name: destrin; corneal disease 1, 2 Jackson
MGI ID: MGI:2388156
Gene: Dstn  Location: Chr2:143757251-143785244 bp, + strand  Genetic Position: Chr2, 70.89 cM, cytoband H1
Strain of Origin:  C57BL/6J
Allele Type:    Spontaneous
Mutation:    Single point mutation
Mutation detailsThe corn1-2J mouse was identified as an allele of corn1 by complementation analysis. The mutation was identifed as a C-to-T transition at coding nucleotide position 316 in exon 3. This mutation results in a Pro106Ser amino acid change that is predicted to affect the binding of the protein to F- and G-actin. (J:83125)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dstn Mutation:  42 strains or lines available
Original:  J:83125 Ikeda S, et al., Aberrant actin cytoskeleton leads to accelerated proliferation of corneal epithelial cells in mice deficient for destrin (actin depolymerizing factor). Hum Mol Genet. 2003 May 1;12(9):1029-37
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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