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Targeted Allele Detail
Symbol: Ddr2tm1Kln
Name: discoidin domain receptor family, member 2; targeted mutation 1, Rudiger Klein
MGI ID: MGI:2388155
Synonyms: DDR2-
Gene: Ddr2  Location: Chr1:169972307-170110762 bp, - strand  Genetic Position: Chr1, 76.84 cM, cytoband H1-H5
Skull comparison of Ddr1tm1Wfv/Ddr1tm1Wfv, Ddr2tm1Kln/Ddr2tm1Kln and Ddr2tm1Kln/Ddr2+ mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:74580
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe exon encoding the ATP binding region of the kinase domain was replaced by a neo cassette inserted by homologous recombination. The absence of normal trancsript and normal protein was confirmed by Northern and Western blot analyses. In vitro studies showed normal proliferation of fibroblasts derived from homozygous mutant mice after infection with a retrovirus containing the wild-type cDNA. (J:74580)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddr2 Mutation:  21 strains or lines available
Original:  J:74580 Labrador JP, et al., The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep. 2001 May;2(5):446-52
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory