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Targeted Allele Detail
Symbol: Mat1atm1Jmm
Name: methionine adenosyltransferase I, alpha; targeted mutation 1, Jose M Mato
MGI ID: MGI:2388143
Gene: Mat1a  Location: Chr14:41105381-41124412 bp, + strand  Genetic Position: Chr14, 22.36 cM, cytoband C1
Liver histology from 8 month old Mat1atm1Jmm/Mat1atm1Jmm mice fed a normal diet

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:69408
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe gene was disrupted by insertion of a PGK-neo cassette into exon 3 via homologous recombination. Absence of gene expression in homozygous mutant animals was verified by Northern and Western blot of liver RNA and proteins. (J:69408)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mat1a Mutation:  2 strains or lines available
Expression of Mat2a mRNA was induced 3-fold in homozygous mutant animals. Expression of Afp mRNA was also increased in homozygous mutants.

Original:  J:69408 Lu SC, et al., Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5560-5
All:  7 reference(s)

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MGI 6.01
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