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Targeted Allele Detail
Symbol: Fxr2tm1Cgr
Name: fragile X mental retardation, autosomal homolog 2; targeted mutation 1, Ben Oostra
MGI ID: MGI:2388128
Synonyms: Fxr2 -
Gene: Fxr2  Location: Chr11:69523816-69544123 bp, + strand  Genetic Position: Chr11, 42.86 cM
Germline Transmission:  Earliest citation of germline transmission: J:75389
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 7 and surrounding intronic sequence was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis of testis and brain tissue, as well as immunohistochemical analysis, indicated an absence of protein in homozygous mutant mice. (J:75389)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fxr2 Mutation:  33 strains or lines available
Original:  J:75389 Bontekoe CJ, et al., Knockout mouse model for Fxr2: a model for mental retardation. Hum Mol Genet. 2002 Mar 1;11(5):487-98
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory