About   Help   FAQ
Fxr2tm1Cgr
Targeted Allele Detail
Nomenclature
Symbol: Fxr2tm1Cgr
Name: fragile X mental retardation, autosomal homolog 2; targeted mutation 1, Ben Oostra
MGI ID: MGI:2388128
Synonyms: Fxr2 -
Gene: Fxr2  Location: Chr11:69523816-69544123 bp, + strand  Genetic Position: Chr11, 42.86 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75389
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 7 and surrounding intronic sequence was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis of testis and brain tissue, as well as immunohistochemical analysis, indicated an absence of protein in homozygous mutant mice. (J:75389)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fxr2 Mutation:  33 strains or lines available
References
Original:  J:75389 Bontekoe CJ, et al., Knockout mouse model for Fxr2: a model for mental retardation. Hum Mol Genet. 2002 Mar 1;11(5):487-98
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/23/2021
MGI 6.17
The Jackson Laboratory