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Ghrtm1Jjk
Targeted Allele Detail
Summary
Symbol: Ghrtm1Jjk
Name: growth hormone receptor; targeted mutation 1, John J Kopchick
MGI ID: MGI:2388126
Synonyms: BH-R-KO, GHR-, GHR/BP-, GHR/BP-deficient, GHRko, GHR-KO, Laron dwarf
Gene: Ghr  Location: Chr15:3347237-3612834 bp, - strand  Genetic Position: Chr15, 1.84 cM
Alliance: Ghrtm1Jjk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:44604
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4 and 500 bp of downstream intronic sequences were replaced with a neomycin resistance cassette via homologous recombination. Northern blot and RT-PCR analysis of liver mRNA from homozygous mutant animals failed to detect gene expression. Western blot analysis of homozygous mutant liver samples did not detect protein product. (J:44604)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 29 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Ghrtm1Jjk
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ghr Mutation:  48 strains or lines available
References
Original:  J:44604 Zhou Y, et al., A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13215-20
All:  133 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory