Ghrtm1Jjk
Targeted Allele Detail
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Symbol: |
Ghrtm1Jjk |
Name: |
growth hormone receptor; targeted mutation 1, John J Kopchick |
MGI ID: |
MGI:2388126 |
Synonyms: |
BH-R-KO, GHR-, GHR/BP-, GHR/BP-deficient, GHRko, GHR-KO, Laron dwarf |
Gene: |
Ghr Location: Chr15:3347237-3612834 bp, - strand Genetic Position: Chr15, 1.84 cM
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Alliance: |
Ghrtm1Jjk page
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Germline Transmission: |
Earliest citation of germline transmission:
J:44604
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 4 and 500 bp of downstream intronic sequences were replaced with a neomycin resistance cassette via homologous recombination. Northern blot and RT-PCR analysis of liver mRNA from homozygous mutant animals failed to detect gene expression. Western blot analysis of homozygous mutant liver samples did not detect protein product.
(J:44604)
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View phenotypes and curated references for all genotypes (concatenated display).
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List all tumor models in MMHCdb carrying
Ghrtm1Jjk
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ghr Mutation: |
48 strains or lines available
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Original: |
J:44604 Zhou Y, et al., A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13215-20 |
All: |
133 reference(s) |
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