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Ghrtm1Jjk
Targeted Allele Detail
Nomenclature
Symbol: Ghrtm1Jjk
Name: growth hormone receptor; targeted mutation 1, John J Kopchick
MGI ID: MGI:2388126
Synonyms: BH-R-KO, GHR-, GHR/BP-, GHR/BP-deficient, GHRko, GHR-KO, Laron dwarf
Gene: Ghr  Location: Chr15:3317755-3583352 bp, - strand  Genetic Position: Chr15, 1.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:44604
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4 and 500 bp of downstream intronic sequences were replaced with a neomycin resistance cassette via homologous recombination. Northern blot and RT-PCR analysis of liver mRNA from homozygous mutant animals failed to detect gene expression. Western blot analysis of homozygous mutant liver samples did not detect protein product. (J:44604)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 29 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ghr Mutation:  3 strains or lines available
References
Original:  J:44604 Zhou Y, et al., A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13215-20
All:  88 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory