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Targeted Allele Detail
Symbol: Mnat1tm1Tpm
Name: menage a trois 1; targeted mutation 1, Tomi P Makela
MGI ID: MGI:2388119
Synonyms: Mat1(-)
Gene: Mnat1  Location: Chr12:73123717-73273988 bp, + strand  Genetic Position: Chr12, 30.37 cM, cytoband C3
Germline Transmission:  Earliest citation of germline transmission: J:69926
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn exon encoding 51 N-terminal amino acids comprising most of the RING finger domain was deleted and replaced with a PGK-neo cassette via homologous recombination. Western blot analysis of correctly targeted ES cells showed no detectable protein expression. Homozygous mutant embryos were observed at day E4.0 by PCR genotype analysis. (J:69926)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mnat1 Mutation:  21 strains or lines available
Homozygous mutant embryos are inviable and die shortly after implantation.
Original:  J:69926 Rossi DJ, et al., Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1. EMBO J. 2001 Jun 1;20(11):2844-56
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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