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Targeted Allele Detail
Symbol: Sstr2tm1Rgs
Name: somatostatin receptor 2; targeted mutation 1, Roy G Smith
MGI ID: MGI:2388099
Synonyms: sst2-, SSTR2-
Gene: Sstr2  Location: Chr11:113619342-113626028 bp, + strand  Genetic Position: Chr11, 79.05 cM
Germline Transmission:  Earliest citation of germline transmission: J:43192
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details1.2 kb of coding region was deleted and replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by Northern blot analysis of brain RNA from homozygous mutant animals using a full-length cDNA probe. (J:43192)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sstr2 Mutation:  18 strains or lines available
Original:  J:43192 Zheng H, et al., Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons. Mol Endocrinol. 1997 Oct;11(11):1709-17
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory