About   Help   FAQ
Sstr2tm1Rgs
Targeted Allele Detail
Nomenclature
Symbol: Sstr2tm1Rgs
Name: somatostatin receptor 2; targeted mutation 1, Roy G Smith
MGI ID: MGI:2388099
Synonyms: sst2-, SSTR2-
Gene: Sstr2  Location: Chr11:113619342-113626028 bp, + strand  Genetic Position: Chr11, 79.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43192
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details1.2 kb of coding region was deleted and replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by Northern blot analysis of brain RNA from homozygous mutant animals using a full-length cDNA probe. (J:43192)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sstr2 Mutation:  15 strains or lines available
References
Original:  J:43192 Zheng H, et al., Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons. Mol Endocrinol. 1997 Oct;11(11):1709-17
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/08/2017
MGI 6.10
The Jackson Laboratory