About   Help   FAQ
Targeted Allele Detail
Symbol: Fgfr3tm1.1Iwa
Name: fibroblast growth factor receptor 3; targeted mutation 1.1, Tomoko Iwata
MGI ID: MGI:2388062
Synonyms: Fgf3K644M, SADDAN
Gene: Fgfr3  Location: Chr5:33721674-33737067 bp, + strand  Genetic Position: Chr5, 17.83 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:70061
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Constitutively active)
Mutation:    Nucleotide substitutions
Mutation detailsFgfr3tm1Iwa animals carry a lysine to methionine substitution at residue 644 (K644M) of exon 10 and a floxed neo cassette in intron 10. The neo cassette was removed by crossing Fgfr3tm1Iwa mutants to the cre expressing line, TgN(EIIa-cre)C5379Lmgd. Northern blot analysis of brain RNA from mutant animals showed a similar level of gene expression as wild-type. (J:70061)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr3 Mutation:  29 strains or lines available
Original:  J:70061 Iwata T, et al., Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice. Hum Mol Genet. 2001 Jun 1;10(12):1255-64
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory