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Gene trapped Allele Detail
Symbol: Ltbp4Gt(U3Cre)1Vmel
Name: latent transforming growth factor beta binding protein 4; gene trap 1, Harald von Melchner
MGI ID: MGI:2388061
Synonyms: 3C7, Ltbp4S-
Gene: Ltbp4  Location: Chr7:27305136-27337692 bp, - strand  Genetic Position: Chr7, 15.87 cM
Mutant Cell Line:  3C7 (Harald von Melchner)
Germline Transmission:  Earliest citation of germline transmission: J:85162
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Gene trapped (Modified isoform(s))
Mutation:    Insertion of gene trap vector     Vector Type: gene trap
Mutation detailsA retroviral gene trap vector, containing cre recombinase and U3 sequences, integrated into intron 5 in a reverse transcriptional orientation. A 98% reduction in mRNA levels was identified in homozygous mutant mice by Northern blot analysis. Western blot analysis results were correlative. (J:47007, J:78819)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ltbp4 Mutation:  73 strains or lines available
Original:  J:78819 Sterner-Kock A, et al., Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. Genes Dev. 2002 Sep 1;16(17):2264-73
All:  10 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory