Apcs^tm1Smae
Targeted Allele Detail

Summary

• Symbol: Apcs^tm1Smae
• Name: amyloid P component, serum; targeted mutation 1, Shuichiro Maeda
• MGI ID: MGI:2388056
• Synonyms: sap^-
• Gene: Apcs Location: Chr1:172721528-172722516 bp, - strand Genetic Position: Chr1, 80.33 cM
• Alliance: Apcs^tm1Smae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79398
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, 0.3 kb of flanking upstream sequences, and 50 bp of exon 2 were deleted and replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of serum protein. (J:79398)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apcs Mutation: 21 strains or lines available

References

• Original: J:79398 Togashi S, et al., Serum amyloid P component enhances induction of murine amyloidosis. Lab Invest. 1997 Nov;77(5):525-31
• All: 2 reference(s)