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Targeted Allele Detail
Symbol: Pik3cdtm1Tnr
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; targeted mutation 1, Martin Turner
MGI ID: MGI:2388047
Synonyms: p110delta-, Pik3cdtm1Tnr
Gene: Pik3cd  Location: Chr4:149649168-149702566 bp, - strand  Genetic Position: Chr4, 80.15 cM
Germline Transmission:  Earliest citation of germline transmission: J:79133
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExons 1 through 9, encoding the first 490 amino acids, were deleted by homologous recombination of floxed selection genes followed by cre mediated excision in male germ cells. Targeting was done in PC3 ES cells which are homozygous for a protamine-cre transgene, Tg(Prm-cre)70Og, which expresses Cre recombinase only in halpoid spermatids. Normal protein was undetected by Western blot analysis of thymocytes obtained from homozygous mutant mice. (J:79133)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3cd Mutation:  14 strains or lines available
Original:  J:79133 Clayton E, et al., A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J Exp Med. 2002 Sep 16;196(6):753-63
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory