Tg(Plp)66Kan
Transgene Detail

Summary

• Symbol: Tg(Plp)66Kan
• Name: transgene insertion 66, Klaus-Armin Nave
• MGI ID: MGI:2388028
• Synonyms: Plp1tg, PLP-tg, PLP-tg⁶⁶
• Transgene: Tg(Plp)66Kan Location: unknown
• Alliance: Tg(Plp)66Kan page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Plp)66Kan expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Plp1 (MGI:97623)

• Mutation details: The complete transcription unit of the mouse Plp gene, including 3.5 kb of 5' regulatory sequence was used to create this transgenic mouse. Lines 66 and 72 were generated (7 and 3 copies of the transgene respectively). Lines 66 and 72 were generated (7 and 3 copies of the transgene respectively). (J:17373)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

In addition to transgenic line 66, a second founder line (line 72) was also generated. Although similar phenotypic characteristics were observed between lines 66 and 72, the majority of the analysis was performed using line 66.

References

• Original: J:17373 Readhead C, et al., Premature arrest of myelin formation in transgenic mice with increased proteolipid protein gene dosage. Neuron. 1994 Mar;12(3):583-95
• All: 21 reference(s)