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Targeted Allele Detail
Symbol: Ambptm1Kkm
Name: alpha 1 microglobulin/bikunin; targeted mutation 1, Koji Kimata
MGI ID: MGI:2388018
Synonyms: Bik-, IaI-
Gene: Ambp  Location: Chr4:63143275-63154799 bp, - strand  Genetic Position: Chr4, 33.96 cM, cytoband C1-C3
Impaired cumulus expansion and oocyte fertilization in Ambptm1Kkm/Ambptm1Kkm female mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:68027
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neo-derived cassette replaced exon 7 and the downstream intron via homologous recombination. The neo cassette introduces translation termination codons before serine 7 of the bikunin protein. The alpha 1 microglobulin sequence, which is translated as a fusion protein with bikunin, remains unchanged. (J:68027)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Ambp Mutation:  16 strains or lines available
Original:  J:68027 Zhuo L, et al., Defect in SHAP-hyaluronan complex causes severe female infertility. A study by inactivation of the bikunin gene in mice. J Biol Chem. 2001 Mar 16;276(11):7693-6
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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